大鼠脂肪细胞中缺乏功能性抗脂解α2-肾上腺素能受体：与仓鼠脂肪细胞的比较。
Lack of functional antilipolytic alpha 2-adrenoceptor in rat fat cell:comparison with hamster adipocyte.
作者信息
Carpene C, Berlan M, Lafontan M
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;74(1):41-5. doi: 10.1016/0742-8413(83)90145-7.
PMID:6132772
Abstract
- The small population of [3H]clonidine binding sites in rat fat cell membranes do not have the characteristics of typical alpha 2-adrenoceptors. 2. Clonidine (an alpha 2-adrenoceptor agonist) has no antilipolytic effect on rat fat cells stimulated by theophylline. 3. In contrast to the rat, [3H]clonidine labels an alpha 2-adrenoceptor in hamster fat cell membranes and clonidine exerts a strong antilipolytic effect on theophylline-stimulated lipolysis.
摘要
- 大鼠脂肪细胞膜中[3H]可乐定结合位点的数量较少，不具备典型α2-肾上腺素能受体的特征。2. 可乐定（一种α2-肾上腺素能受体激动剂）对茶碱刺激的大鼠脂肪细胞没有抗脂解作用。3. 与大鼠不同，[3H]可乐定标记仓鼠脂肪细胞膜中的α2-肾上腺素能受体，且可乐定对茶碱刺激的脂解作用有很强的抗脂解作用。
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