内毒素对金黄仓鼠的致畸作用。

Teratogenic effects of endotoxin on the golden hamster.

作者信息

Lanning J C, Hilbelink D R, Chen L T

出版信息

Teratog Carcinog Mutagen. 1983;3(2):145-9. doi: 10.1002/1520-6866(1990)3:2<145::aid-tcm1770030206>3.0.co;2-u.

DOI:10.1002/1520-6866(1990)3:2<145::aid-tcm1770030206>3.0.co;2-u

Abstract

Gram-negative urinary tract infections in pregnant women have been implicated as causes of maternal endotoxemia and a subsequent higher incidence of malformations in their offspring. A study was performed to evaluate the effects of endotoxin on the development of the golden hamster. Endotoxin was shown to be extremely embryolethal at higher doses and to produce several malformations at lower doses. The pregnant hamster and its developing embryos were observed to be far more sensitive to endotoxin than species examined by other investigators.

摘要

孕妇革兰氏阴性尿路感染被认为是导致母体内毒素血症的原因，以及其后代出现更高畸形发生率的后续因素。进行了一项研究以评估内毒素对金黄地鼠发育的影响。结果表明，高剂量内毒素具有极高的胚胎致死性，低剂量时会产生多种畸形。观察到怀孕的仓鼠及其发育中的胚胎对内毒素的敏感性远高于其他研究者所检测的物种。