大肠杆菌和牙龈卟啉单胞菌脂多糖对金黄仓鼠妊娠结局的影响。
Effects of Escherichia coli and Porphyromonas gingivalis lipopolysaccharide on pregnancy outcome in the golden hamster.
作者信息
Collins J G, Smith M A, Arnold R R, Offenbacher S
机构信息
School of Dentistry, Dental Research Center, University of North Carolina at Chapel Hill 27599-7455.
出版信息
Infect Immun. 1994 Oct;62(10):4652-5. doi: 10.1128/iai.62.10.4652-4655.1994.
Abstract
This report describes the effects of two gram-negative bacterial endotoxin (lipopolysaccharide [LPS]) preparations on hamster pregnancy outcome variables. Single intravenous challenges with Escherichia coli and Porphyromonas gingivalis LPS on day 8 of pregnancy produced dose-dependent effects on fetal weight malformation and fetal resorption with E. coli LPS having potent embryolethal effects. Premating maternal exposure to P. gingivalis produced embryolethal effects similar to those of E. coli. These data suggest that maternal exposure to P. gingivalis LPS prior to and during pregnancy can induce deleterious effects on the developing fetus.
摘要
本报告描述了两种革兰氏阴性细菌内毒素（脂多糖[LPS]）制剂对仓鼠妊娠结局变量的影响。在妊娠第8天单次静脉注射大肠杆菌和牙龈卟啉单胞菌LPS，对胎儿体重、畸形和胎儿吸收产生剂量依赖性影响，其中大肠杆菌LPS具有强大的胚胎致死作用。妊娠前母体暴露于牙龈卟啉单胞菌产生的胚胎致死作用与大肠杆菌相似。这些数据表明，母体在妊娠前和妊娠期间暴露于牙龈卟啉单胞菌LPS可对发育中的胎儿产生有害影响。
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