雷尼替丁对利多卡因处置无影响。
Lack of effect of ranitidine on the disposition of lignocaine.
作者信息
Feely J, Guy E
出版信息
Br J Clin Pharmacol. 1983 Mar;15(3):378-9. doi: 10.1111/j.1365-2125.1983.tb01514.x.
Abstract
Cimetidine has been shown to alter the disposition of lignocaine and other drugs that are highly extracted by the liver. In a placebo controlled study ranitidine (150 mg twice daily) did not alter the elimination half-life, systemic clearance or distribution of lignocaine (mg/kg) in six healthy subjects. The interaction with cimetidine appears to be unrelated to histamine H2-receptor antagonism.
摘要
已证明西咪替丁可改变利多卡因及其他经肝脏高度摄取的药物的处置过程。在一项安慰剂对照研究中，雷尼替丁（每日两次，每次150毫克）并未改变6名健康受试者体内利多卡因的消除半衰期、全身清除率或分布（毫克/千克）。与西咪替丁的相互作用似乎与组胺H2受体拮抗作用无关。
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本文引用的文献
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Increased toxicity and reduced clearance of lidocaine by cimetidine.西咪替丁增加利多卡因的毒性并降低其清除率。
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