雷尼替丁对美托洛尔处置的影响。
Effects of ranitidine on the disposition of metoprolol.
作者信息
Kelly J G, Salem S A, Kinney C D, Shanks R G, McDevitt D G
出版信息
Br J Clin Pharmacol. 1985 Feb;19(2):219-24. doi: 10.1111/j.1365-2125.1985.tb02634.x.
Abstract
The effects of ranitidine on the pharmacokinetics of metoprolol were examined in two studies. In the first study, pharmacokinetics of single doses of metoprolol were examined in six subjects before, during and after ranitidine administration for 1 week. Peak concentrations of metoprolol were increased on ranitidine but its half-life and clearance were unaltered. In the second study, 12 subjects received metoprolol twice daily for 1 week; once with ranitidine and once with placebo. Ranitidine had no effects on the chronic-dose pharmacokinetics or pharmacodynamics of metoprolol. The chronic dose study suggests no inhibition of the metabolism of metoprolol by ranitidine. The single dose study suggests, however, that some interaction of an as yet unknown nature, cannot be excluded.
摘要
两项研究考察了雷尼替丁对美托洛尔药代动力学的影响。在第一项研究中，对6名受试者在服用雷尼替丁1周前、期间和之后单剂量服用美托洛尔的药代动力学进行了考察。雷尼替丁使美托洛尔的峰值浓度升高，但其半衰期和清除率未改变。在第二项研究中，12名受试者每天服用美托洛尔两次，共1周；一次与雷尼替丁一起服用，一次与安慰剂一起服用。雷尼替丁对美托洛尔的慢性剂量药代动力学或药效学没有影响。慢性剂量研究表明雷尼替丁不会抑制美托洛尔的代谢。然而，单剂量研究表明，尚不能排除某种性质未知的相互作用。
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