Piersma A H, Ploemacher R E, Brockbank K G
Br J Haematol. 1983 Jun;54(2):285-90. doi: 10.1111/j.1365-2141.1983.tb02097.x.
Kinetics of fibroblastic colony-forming cells (CFU-F) were studied in mouse bone marrow after lethal total body irradiation and intravenous bone marrow transplantation. After an initial decrease, CFU-F numbers recovered, and plateaued 5 weeks post-treatment at 10% of normal values. Using chromosome-marked donor bone marrow cells we found that 1 day after transplantation 72% of donor CFU-F had reached the recipient's bone marrow, indicating a highly specific lodgment of CFU-F. Three months after transplantation donor CFU-F were still detectable and comprised about half of the femoral CFU-F population. It is concluded that CFU-F, a component of the haemopoietic microenvironment, are transplantable via the intravenous route.
在致死性全身照射及静脉内骨髓移植后，对小鼠骨髓中成纤维细胞集落形成细胞（CFU-F）的动力学进行了研究。在最初的减少之后，CFU-F数量恢复，并在治疗后5周稳定在正常值的10%。使用染色体标记的供体骨髓细胞，我们发现移植后1天，72%的供体CFU-F已到达受体骨髓，表明CFU-F具有高度特异性的定位。移植后三个月，仍可检测到供体CFU-F，且约占股骨CFU-F群体的一半。结论是，造血微环境的组成部分CFU-F可通过静脉途径移植。
