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不同增殖状态下造血和基质祖细胞的热敏感性。

Thermal sensitivity of haemopoietic and stromal progenitor cells in different proliferative states.

作者信息

Wang S B, Hendry J H, Testa N G

出版信息

Br J Cancer. 1985 Jul;52(1):51-4. doi: 10.1038/bjc.1985.147.

DOI:10.1038/bjc.1985.147
PMID:4015952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1977179/
Abstract

Stromal progenitor cells (CFU-F) in normal mouse bone marrow were more sensitive to heat at 43 degrees C than haemopoietic progenitor cells (CFU-S and GM-CFC) by a factor of approximately 1.2. In marrow regenerating after 4.5 Gy X-rays, the changes in sensitivity were by less than a factor of 1.4 and the sensitivity of CFU-F changed slightly to become intermediate between that of CFU-S and GM-CFC. A comparison of sensitivities reported in the literature revealed an inexplicable large variation of up to a factor of 6 in the thermal sensitivities of CFU-S and GM-CFC.

摘要

正常小鼠骨髓中的基质祖细胞（CFU-F）在43℃时对热的敏感性比造血祖细胞（CFU-S和GM-CFC）高约1.2倍。在4.5 Gy X射线照射后再生的骨髓中，敏感性变化小于1.4倍，CFU-F的敏感性略有变化，变为介于CFU-S和GM-CFC之间。文献报道的敏感性比较显示，CFU-S和GM-CFC的热敏感性存在高达6倍的无法解释的巨大差异。

相似文献

1
Thermal sensitivity of haemopoietic and stromal progenitor cells in different proliferative states.不同增殖状态下造血和基质祖细胞的热敏感性。
Br J Cancer. 1985 Jul;52(1):51-4. doi: 10.1038/bjc.1985.147.
2
The sensitivity to hyperthermia of human granulocyte/macrophage progenitor cells (CFU-GM) derived from blood or marrow of normal subjects and patients with chronic granulocytic leukaemia.源自正常受试者以及慢性粒细胞白血病患者的血液或骨髓的人粒细胞/巨噬细胞祖细胞（CFU-GM）对热疗的敏感性。
Br J Cancer. 1984 Dec;50(6):745-51. doi: 10.1038/bjc.1984.251.
3
Recovery of the proliferative and functional integrity of mouse bone marrow in long-term cultures established after whole-body irradiation at different doses and dose rates.在不同剂量和剂量率的全身照射后建立的长期培养中，小鼠骨髓增殖和功能完整性的恢复。
Exp Hematol. 1991 Feb;19(2):81-6.
4
Cell cycle-dependent heat sensitization of murine granulocyte-macrophage progenitor cells in regenerating marrow.
Cancer Res. 1985 Apr;45(4):1459-63.
5
Greater sparing of stromal progenitor cells than of haemopoietic stem cells in gamma-irradiated mouse marrow using low dose-rates.
Biomed Pharmacother. 1984;38(7):356-8.
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In vivo studies on the regeneration kinetics of enriched populations of haemopoietic spleen colony-forming cells from normal bone marrow.关于正常骨髓中造血脾集落形成细胞富集群体再生动力学的体内研究。
Cell Tissue Kinet. 1983 Jul;16(4):385-92.
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Cell Tissue Kinet. 1983 Jul;16(4):375-83.
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本文引用的文献

1
A comparison of the response to hyperthermia of murine haemopoietic stem cells (CFU-S) and L1210 leukaemia cells: enhanced killing of leukaemic cells in presence of normal marrow cells.小鼠造血干细胞（CFU-S）和L1210白血病细胞对热疗反应的比较：在正常骨髓细胞存在下白血病细胞的杀伤增强。
Br J Cancer. 1981 Nov;44(5):682-91. doi: 10.1038/bjc.1981.254.
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Response of human hematopoietic precursor cells (CFUc) to hyperthermia and radiation.人类造血前体细胞（CFUc）对热疗和辐射的反应。
Cancer Res. 1982 Apr;42(4):1261-5.
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The separation of a mixture of bone marrow stem cells from tumor cells: an essential step for autologous bone marrow transplantation.从肿瘤细胞中分离骨髓干细胞混合物：自体骨髓移植的关键步骤。
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4
Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny.人骨髓成纤维细胞集落形成细胞（CFU-F）及其子代的特性分析。
Blood. 1980 Aug;56(2):289-301.
5
Stromal colonies from mouse marrow: characterization of cell types, optimization of plating efficiency and its effect on radiosensitivity.小鼠骨髓的基质集落：细胞类型的特征、接种效率的优化及其对放射敏感性的影响。
J Cell Sci. 1983 May;61:453-66. doi: 10.1242/jcs.61.1.453.
6
Differential sensitivity of AKR murine leukemia and normal bone marrow cells to hyperthermia.AKR小鼠白血病细胞和正常骨髓细胞对热疗的敏感性差异
Cancer Res. 1983 Oct;43(10):4951-5.
7
The effect of hyperthermia on hemopoietic progenitor cells of the mouse.高温对小鼠造血祖细胞的影响。
Radiat Res. 1983 Jul;95(1):142-9.
8
Heat sensitivities of murine normal and leukaemic haemopoietic stem cells: thermal inactivation energy and dependence on nutritional milieu.小鼠正常和白血病造血干细胞的热敏感性：热失活能量及对营养环境的依赖性
Br J Radiol. 1984 May;57(677):421-2. doi: 10.1259/0007-1285-57-677-421.
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The response of stromal progenitor cells in mouse marrow to graded repeated doses of X rays or neutrons.
Radiat Res. 1983 Oct;96(1):82-9.
10
Transplantation of bone marrow fibroblastoid stromal cells in mice via the intravenous route.通过静脉途径将骨髓成纤维样基质细胞移植到小鼠体内。
Br J Haematol. 1983 Jun;54(2):285-90. doi: 10.1111/j.1365-2141.1983.tb02097.x.