不同增殖状态下造血和基质祖细胞的热敏感性。
Thermal sensitivity of haemopoietic and stromal progenitor cells in different proliferative states.
作者信息
Wang S B, Hendry J H, Testa N G
出版信息
Br J Cancer. 1985 Jul;52(1):51-4. doi: 10.1038/bjc.1985.147.
Abstract
Stromal progenitor cells (CFU-F) in normal mouse bone marrow were more sensitive to heat at 43 degrees C than haemopoietic progenitor cells (CFU-S and GM-CFC) by a factor of approximately 1.2. In marrow regenerating after 4.5 Gy X-rays, the changes in sensitivity were by less than a factor of 1.4 and the sensitivity of CFU-F changed slightly to become intermediate between that of CFU-S and GM-CFC. A comparison of sensitivities reported in the literature revealed an inexplicable large variation of up to a factor of 6 in the thermal sensitivities of CFU-S and GM-CFC.
摘要
正常小鼠骨髓中的基质祖细胞（CFU-F）在43℃时对热的敏感性比造血祖细胞（CFU-S和GM-CFC）高约1.2倍。在4.5 Gy X射线照射后再生的骨髓中，敏感性变化小于1.4倍，CFU-F的敏感性略有变化，变为介于CFU-S和GM-CFC之间。文献报道的敏感性比较显示，CFU-S和GM-CFC的热敏感性存在高达6倍的无法解释的巨大差异。
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Thermal sensitivity of haemopoietic and stromal progenitor cells in different proliferative states.不同增殖状态下造血和基质祖细胞的热敏感性。
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