Comparative aspects of central cardiovascular control with special reference to adrenergic mechanisms.

1. The central nervous system probably serves as an overall cardiovascular regulatory centre in all vertebrates. 2. Electrical stimulation of the brain elicits haemodynamic effects in all vertebrate classes, but the quality of the responses may differ between different classes in some cases. 3. In the most "primitive" classes of vertebrates, i.e. fishes, the circulatory regulation may be exerted via mechanisms somewhat different from those in other vertebrates. 4. Amphibians, reptiles, birds and mammals display a similar cardiovascular response pattern to administration of drugs such as clonidine and L-DOPA.