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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Hillman G R, Ewert A, Westerfield L, Grim S O

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;74(2):299-301. doi: 10.1016/0742-8413(83)90104-4.

Several drugs were tested as inhibitors of the body movements of adult Brugia malayi. 2. Atropine, carbachol, DDNS (a fluorescent acetylcholine analog), diethylcarbamazine, and physostigmine caused significant reduction in motor activity. 3. Glutamate, hexamethonium, muscarine, norepinephrine, serotonin and d-tubocurarine had no effect. Three novel phosphonium compounds were tested as inhibitors of Brugia and vertebrate acetylcholinesterase. 4. Two of these produced preferential inhibition of the enzyme from Brugia.

对几种药物进行了测试，以确定它们对成年马来布鲁线虫身体运动的抑制作用。2. 阿托品、卡巴胆碱、DDNS（一种荧光乙酰胆碱类似物）、乙胺嗪和毒扁豆碱导致运动活性显著降低。3. 谷氨酸、六甲铵、毒蕈碱、去甲肾上腺素、5-羟色胺和d-筒箭毒碱没有作用。测试了三种新型鏻化合物作为布鲁线虫和脊椎动物乙酰胆碱酯酶的抑制剂。4. 其中两种对布鲁线虫的酶产生了优先抑制作用。

Hillman G R, Ewert A, Westerfield L, Grim S O

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;74(2):299-301. doi: 10.1016/0742-8413(83)90104-4.

Several drugs were tested as inhibitors of the body movements of adult Brugia malayi. 2. Atropine, carbachol, DDNS (a fluorescent acetylcholine analog), diethylcarbamazine, and physostigmine caused significant reduction in motor activity. 3. Glutamate, hexamethonium, muscarine, norepinephrine, serotonin and d-tubocurarine had no effect. Three novel phosphonium compounds were tested as inhibitors of Brugia and vertebrate acetylcholinesterase. 4. Two of these produced preferential inhibition of the enzyme from Brugia.

对几种药物进行了测试，以确定它们对成年马来布鲁线虫身体运动的抑制作用。2. 阿托品、卡巴胆碱、DDNS（一种荧光乙酰胆碱类似物）、乙胺嗪和毒扁豆碱导致运动活性显著降低。3. 谷氨酸、六甲铵、毒蕈碱、去甲肾上腺素、5-羟色胺和d-筒箭毒碱没有作用。测试了三种新型鏻化合物作为布鲁线虫和脊椎动物乙酰胆碱酯酶的抑制剂。4. 其中两种对布鲁线虫的酶产生了优先抑制作用。