Denham D A, Suswillo R R, Rogers R, McGreevy P B
J Parasitol. 1978 Jun;64(3):463-8.
Diethylcarbamazine (DEC) was active in vitro against infective larvae and microfilariae of Brugia pahangi but only at high concentrations. When fed to mosquitoes which were infected with B. pahangi it had little or no activity. In jirds it was inactive against B. pahangi microfilariae and adults when administered at 300 mg/kg for 5 days either by the intraperitoneal or oral route. In cats given 25 or 50 mg DEC/kg intraperitoneally on 3 or 5 occasions it was not microfilaricidal, but most of the adult worms died within 30 days of the end of treatment. Although most microfilariae disappeared from the blood of cats immediately (i.e., within an hour) after treatment, they reappeared within a few hours in the same numbers. Microfilarial levels were reduced after treatment but there was no precipitate decline as occurs in human B. malayi patients.
乙胺嗪（DEC）在体外对彭亨丝虫的感染性幼虫和微丝蚴有活性，但仅在高浓度时有效。当喂食感染了彭亨丝虫的蚊子时，它几乎没有活性。在沙土鼠中，通过腹腔内或口服途径以300mg/kg的剂量给药5天，它对彭亨丝虫微丝蚴和成虫无活性。在猫中，3次或5次腹腔内给予25或50mg DEC/kg，它不具有杀微丝蚴作用，但大多数成虫在治疗结束后30天内死亡。虽然大多数微丝蚴在治疗后立即（即1小时内）从猫的血液中消失，但它们在几小时内又以相同数量重新出现。治疗后微丝蚴水平降低，但没有像马来丝虫病患者那样出现急剧下降。
