Ewert A, Emerson G A
Am J Trop Med Hyg. 1975 Jan;24(1):71-3. doi: 10.4269/ajtmh.1975.24.71.
Forty-one experimental and 37 control cats were each infected with 50 Brugia malayi larvae in such a way that a preponderance of the larvae remained localized in the popliteal lymph node or in the lymphatics of the leg draining into that node. During the 1st week after infection cats were treated with varying doses of diethylcarbamazine citrate (DEC). Two weeks after infection, necropsy for worm recovery was performed on treated and control cats. No living larva was recovered from 21 of 22 cats treated with a total of 10 mg DEC/kg body weight or greater. A single living larva was recovered in only 2 of 5 cats treated at 5 mg/kg. At 2 mg/kg, 8 of 10 cats had substantially fewer larvae than their controls; the remaining 2 were negative. In 4 cats treated with a total of 1 mg/kg, there was no reduction of larvae. All 37 untreated controls harbored living larvae, with a mean of 56% of the inoculum being recovered.
41只实验猫和37只对照猫分别感染了50条马来布鲁线虫幼虫，感染方式使得大部分幼虫局限于腘淋巴结或引流至该淋巴结的腿部淋巴管中。在感染后的第1周，用不同剂量的枸橼酸乙胺嗪（DEC）对猫进行治疗。感染后两周，对治疗组和对照组的猫进行尸检以回收虫体。在总共接受10mg DEC/kg体重或更高剂量治疗的22只猫中，有21只未回收活幼虫。在以5mg/kg治疗的5只猫中，只有2只回收了1条活幼虫。在以2mg/kg治疗的10只猫中，8只的幼虫数量比其对照组大幅减少；其余2只为阴性。在总共接受1mg/kg治疗的4只猫中，幼虫数量没有减少。所有37只未治疗的对照组都有活幼虫，回收的幼虫平均占接种量的56%。
