Davies R, Slater J D
Lancet. 1976 Sep 18;2(7986):594-6. doi: 10.1016/s0140-6736(76)90665-6.
Two beta-blocking agents with different properties were used to define the adrenergic component of the renin release which follows orthostasis. Five normal young subjects were tilted to 85 degrees for 30 min on four separate occasions. In two control studies the release of renin, as indicated by changes in plasma-renin activity, was highly reproducible. The effects of intravenous oxprenolol and intravenous propranolol, were then compared under the same experimental conditions. Oxprenolol attenuated the renin response in all subjects without completely abolishing it. Propranolol completely abolished the renin response. The difference in the ability of these agents to suppress renin release may be related to the presence (oxprenolol) or absence (propranolol) of intrinsic sympathomimetic activity. The increased rate of renin release in orthostasis seems to be mediated entirely by the adrenergic nervous system.
使用两种具有不同特性的β受体阻滞剂来确定直立位后肾素释放的肾上腺素能成分。五名正常年轻受试者在四个不同的场合被倾斜至85度并保持30分钟。在两项对照研究中，血浆肾素活性的变化所表明的肾素释放具有高度可重复性。然后在相同的实验条件下比较静脉注射氧烯洛尔和静脉注射普萘洛尔的效果。氧烯洛尔减弱了所有受试者的肾素反应，但并未完全消除。普萘洛尔完全消除了肾素反应。这些药物抑制肾素释放能力的差异可能与内在拟交感活性的存在（氧烯洛尔）或不存在（普萘洛尔）有关。直立位时肾素释放速率的增加似乎完全由肾上腺素能神经系统介导。
