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Bopindolol: a new long acting beta-receptor antagonist; its effects on haemodynamics, and on the renin response to tilting.

作者信息

Turner D R, Goodwin F J, Knight A R, Littlejohns D W, Sharman V L, Vere D W

出版信息

Br J Clin Pharmacol. 1984 Mar;17(3):295-9. doi: 10.1111/j.1365-2125.1984.tb02344.x.

DOI:10.1111/j.1365-2125.1984.tb02344.x
PMID:6143566
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1463381/
Abstract

Oral administration of single doses of bopindolol (1-4mg) caused significant reductions in the rises of systolic blood pressure and heart rate produced by exercise; only the reduction in the rise of heart rate was significantly dose-related. Resting heart rate was reduced by bopindolol. There were small effects on resting blood pressure. Bopindolol caused a significant attenuation of the rise in plasma renin activity produced by passive head-up tilting to 75-85 degrees. Bopindolol produced a dose-related attenuation of the increase in pulse rate evoked by passive tilting. All effects 1-4 were maintained for at least 24 h. There was no measurable effect on plasma potassium concentration, peak flow rate or forced expiratory volume (FEV1).

摘要

相似文献

1
Bopindolol: a new long acting beta-receptor antagonist; its effects on haemodynamics, and on the renin response to tilting.
Br J Clin Pharmacol. 1984 Mar;17(3):295-9. doi: 10.1111/j.1365-2125.1984.tb02344.x.
2
Cardiohemodynamic effects of bopindolol in normotensive conscious dogs. A comparative study with pindolol.波吲洛尔对正常血压清醒犬的心脏血流动力学效应。与吲哚洛尔的比较研究。
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3
Hypotensive effect of bopindolol in pithed rats.
Gen Pharmacol. 1993 Mar;24(2):373-5. doi: 10.1016/0306-3623(93)90319-s.
4
Effect of bopindolol on renin secretion and renal excretory function in rats.
J Cardiovasc Pharmacol. 1989 Jun;13(6):862-9. doi: 10.1097/00005344-198906000-00008.
5
Pharmacological experiments in healthy volunteers with bopindolol, a long-acting beta-adrenoceptor blocking drug with partial agonist activity.在健康志愿者身上使用波吲洛尔进行的药理学实验，波吲洛尔是一种具有部分激动剂活性的长效β-肾上腺素能受体阻滞剂。
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6
Effects of chronic oral administration of a new beta-blocker, bopindolol, on serum lipoprotein concentrations and blood pressure of spontaneously hypertensive rats.
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7
The clinical pharmacology of bopindolol, a new long-acting beta-adrenoceptor antagonist, in hypertension.
Clin Pharmacol Ther. 1987 Oct;42(4):411-9. doi: 10.1038/clpt.1987.171.
8
Haemodynamic effects of atenolol and bopindolol at rest and during isometric exercise. A non-invasive study in healthy volunteers.阿替洛尔和波吲洛尔在静息及等长运动时的血流动力学效应。一项针对健康志愿者的非侵入性研究。
Ann Clin Res. 1988;20(6):431-5.
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[Beta-blocking actions and the partial agonist activity of bopindolol, a new beta-adrenoceptor antagonist, and its two metabolites].
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Clinical pharmacological studies with the long-acting beta-adrenoceptor blocking drug bopindolol.
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引用本文的文献

1
Haemodynamic effects of short-term treatment with bopindolol in essential hypertension.
Eur J Clin Pharmacol. 1988;34(4):411-3. doi: 10.1007/BF00542445.
2
Acute and long-term antihypertensive effect of bopindolol--a nonselective beta-adrenergic blocker with ISA.波吲洛尔（一种具有内在拟交感活性的非选择性β肾上腺素能阻滞剂）的急性和长期降压作用
Eur J Clin Pharmacol. 1985;29(3):281-5. doi: 10.1007/BF00544081.
3
Pharmacological experiments in healthy volunteers with bopindolol, a long-acting beta-adrenoceptor blocking drug with partial agonist activity.在健康志愿者身上使用波吲洛尔进行的药理学实验，波吲洛尔是一种具有部分激动剂活性的长效β-肾上腺素能受体阻滞剂。
Br J Clin Pharmacol. 1985 Jun;19(6):775-81. doi: 10.1111/j.1365-2125.1985.tb02713.x.
4
Comparison of bopindolol and atenolol in chronic stable angina pectoris.波吲洛尔与阿替洛尔治疗慢性稳定型心绞痛的比较。
Eur J Clin Pharmacol. 1990;38(1):81-4. doi: 10.1007/BF00314809.
5
Bopindolol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy.波吲洛尔：其药效学、药代动力学特性及治疗效果综述
Drugs. 1991 Jan;41(1):130-49. doi: 10.2165/00003495-199141010-00010.

本文引用的文献

1
Impaired response of plasma renin activity to tilting after renal transplantation.肾移植后血浆肾素活性对倾斜的反应受损。
Clin Sci (Lond). 1981 Jul;61(1):69-73. doi: 10.1042/cs0610069.
2
The renin system: Variations in man measured by radioimmunoassay or bioassay.肾素系统：通过放射免疫测定法或生物测定法测定的人体中的变化。
Kidney Int. 1972 Apr;1(4):240-53. doi: 10.1038/ki.1972.34.
3
Comparison of metoprolol and propranolol in modification of haemodynamic and renin-aldosterone responses to tilting in humans.美托洛尔与普萘洛尔对人体倾斜时血流动力学及肾素-醛固酮反应影响的比较
Clin Sci Mol Med Suppl. 1976 Dec;3:533s-535s. doi: 10.1042/cs051533s.
4
Is the adrenergic control of renin release dominant in man?在人类中，肾素释放的肾上腺素能控制占主导地位吗？
Lancet. 1976 Sep 18;2(7986):594-6. doi: 10.1016/s0140-6736(76)90665-6.