Elmgreen J, Hesse B, Christensen N J
Eur J Clin Pharmacol. 1981;20(5):339-42. doi: 10.1007/BF00615402.
The role of the sympathetic nervous system in furosemide-induced renin release was investigated in six normal subjects. After intravenous administration of furosemide, plasma renin concentrations increased more than two-fold within 15 min. Neither replacement of urinary fluid loss by intravenous infusion of saline nor pharmacological beta-blockade with d,1-propranolol changed the renin response to furosemide. The activity of the sympathetic nervous system, as estimated by measurement of plasma catecholamine concentrations, remained at the reference level after furosemide. It is concluded that the sympathetic nervous system is not involved in renin release after intravenous administration of furosemide.
在六名正常受试者中研究了交感神经系统在速尿诱导肾素释放中的作用。静脉注射速尿后，血浆肾素浓度在15分钟内增加了两倍多。静脉输注生理盐水补充尿液丢失量，或用d，1-普萘洛尔进行药理学β受体阻滞，均未改变肾素对速尿的反应。通过测量血浆儿茶酚胺浓度评估的交感神经系统活性，在速尿给药后仍保持在参考水平。得出的结论是，静脉注射速尿后，交感神经系统不参与肾素释放。
