Toth E, Lajtha A, Sarhan S, Seiler N
Neurochem Res. 1983 Mar;8(3):291-302. doi: 10.1007/BF00965719.
The anticonvulsive effects of GABA, taurine, and glycine were investigated on several chemically-induced and genetic seizure models. Intravenous injections of either GABA, taurine, or glycine provided protection against 3-mercaptopropionic acid (MPA)-induced convulsions in adult Swiss mice. GABA was partially effective against isonicotinic acid hydrazide and was without effect against bicuculline-induced convulsions. Prolonged administration of glycine prevented MPA-induced convulsions but not electrically induced seizures or seizures induced by strychnine or metrazol. Intragastric glycine protected young audiogenic seizure-susceptible DBA/2 mice against all three phases of sound-induced convulsions (wild running, clonic and tonic seizure), but GABA and taurine provided little or no protection. With increase of glycine, the cerebral levels of glutamine and serine also increased, but that of glutamic acid decreased. The endogenous glutamic and glycine levels were slightly higher in the brains of the audiogenic seizure-susceptible DBA/2 mice than in that of the resistant BALB/Cy strain.
研究了γ-氨基丁酸（GABA）、牛磺酸和甘氨酸对几种化学诱导和基因癫痫模型的抗惊厥作用。静脉注射GABA、牛磺酸或甘氨酸可保护成年瑞士小鼠免受3-巯基丙酸（MPA）诱导的惊厥。GABA对异烟肼有部分疗效，但对荷包牡丹碱诱导的惊厥无效。长期给予甘氨酸可预防MPA诱导的惊厥，但对电诱导的惊厥或士的宁或戊四氮诱导的惊厥无效。胃内给予甘氨酸可保护对声音敏感的幼年DBA/2小鼠免受声音诱导惊厥的所有三个阶段（狂奔、阵挛性和强直性惊厥）的影响，但GABA和牛磺酸几乎没有或没有保护作用。随着甘氨酸水平的升高，大脑中谷氨酰胺和丝氨酸水平也升高，但谷氨酸水平降低。对声音敏感的DBA/2小鼠大脑中内源性谷氨酸和甘氨酸水平略高于抗性BALB/Cy品系小鼠。
