Berdichevsky E, Riveros N, Sánchez-Armáss S, Orrego F
Neurosci Lett. 1983 Mar 28;36(1):75-80. doi: 10.1016/0304-3940(83)90489-5.
Kainate (0.62-5 mM) was found to increase the initial rate of influx of 45Ca and of 22Na into the non-inulin space of rat thin brain cortex slices incubated in vitro, and to shorten the equilibration time for both these ions. N-methyl-DL-aspartate (50-1000 microM), L-glutamate (0.62-5 mM), DL-homocysteate (0.62-2.5 mM), and ibotenate (6-170 microM) also significantly increased the influx of 45Ca into the non-inulin space of this preparation, while the non-neurotoxic acidic amino acids N-acetyl-L-aspartate, and alpha-methyl-DL-aspartate (both 1.25-5 mM), did not increase such influx. We suggest that enhanced calcium uptake may represent the basis for the neurotoxic effects of these compounds.
发现 kainate（0.62 - 5 mM）可增加 45Ca 和 22Na 流入体外培养的大鼠薄脑皮层切片非菊粉空间的初始速率，并缩短这两种离子的平衡时间。N - 甲基 - DL - 天冬氨酸（50 - 1000 microM）、L - 谷氨酸（0.62 - 5 mM）、DL - 高半胱氨酸（0.62 - 2.5 mM）和鹅膏蕈氨酸（6 - 170 microM）也显著增加了 45Ca 流入该制剂非菊粉空间的量，而非神经毒性酸性氨基酸 N - 乙酰 - L - 天冬氨酸和α - 甲基 - DL - 天冬氨酸（均为 1.25 - 5 mM）则不会增加这种流入量。我们认为钙摄取增加可能是这些化合物神经毒性作用的基础。
