Lang A E, Sheehy M P, Marsden C D
Adv Neurol. 1983;37:193-200.
We have investigated the effects of the intravenous administration of three anticholinergic drugs (atropine, benztropine, and chlorpheniramine) with variable antihistaminic properties in comparison with saline in adult-onset focal dystonias. In many patients, the severity of the involuntary movements varied from one observation to the next. Patients with spasmodic torticollis, writer's cramp, and segmental dystonia showed little change with any of the active drugs. The occasional individual who improved by more than 20% did so at the expense of drug-induced drowsiness. We conclude that cholinergic mechanisms are not of general importance in the pathogenesis of these conditions. However, the beneficial response to benztropine and chlorpheniramine in two of 20 patients emphasizes the continuing need for a trial-and -error approach in the therapy of these focal dystonias.
我们研究了静脉注射三种具有不同抗组胺特性的抗胆碱能药物（阿托品、苯海索和氯苯那敏）与生理盐水相比，对成人起病的局灶性肌张力障碍的影响。在许多患者中，非自主运动的严重程度在不同观察之间有所变化。痉挛性斜颈、书写痉挛和节段性肌张力障碍患者使用任何一种活性药物后变化都不大。偶尔有改善超过20%的个体，但代价是药物引起的嗜睡。我们得出结论，胆碱能机制在这些疾病的发病机制中并非普遍重要。然而，20名患者中有2名对苯海索和氯苯那敏有有益反应，这强调了在这些局灶性肌张力障碍的治疗中持续采用试错法的必要性。
