Cohen L G, Hallett M, Geller B D, Hochberg F
Human Motor Control Section, NINCDS, Bethesda, MD 20892.
J Neurol Neurosurg Psychiatry. 1989 Mar;52(3):355-63. doi: 10.1136/jnnp.52.3.355.
The effects of botulinum toxin injections have been studied on 19 patients with hand dystonia. The dystonic muscles were identified by clinical examination and EMG findings of localised bursts of muscle activation with fine wire electrodes during the tasks that precipitated the dystonia. Injections into the most active muscles were given to each patient every 2 weeks in increasing doses (up to 20 U the first week, up to 40 U the second week, and up to 80 U the third week) until performance improvement was achieved. Subjective improvement of cramping, pain and/or tension was associated with temporary weakness in injected muscles. Benefit was seen in 16 patients, lasted between 1 and 6 months, and was reproducible.
已经对19例手部肌张力障碍患者进行了肉毒杆菌毒素注射效果的研究。通过临床检查以及在引发肌张力障碍的任务期间使用细线电极记录到的局部肌肉激活突发的肌电图结果来确定肌张力障碍的肌肉。每2周对每位患者最活跃的肌肉进行注射，剂量逐渐增加（第一周最多20单位，第二周最多40单位，第三周最多80单位），直至症状改善。痉挛、疼痛和/或紧张感的主观改善与注射肌肉的暂时无力有关。16例患者出现了疗效，持续时间在1至6个月之间，且可重复出现。
