Bray R S, Heikal B, Kaye P M, Bray M A
Acta Trop. 1983 Mar;40(1):29-38.
Macrophages infected with amastigotes of Leishmania mexicana mexicana as compared to normal macrophages show decreased migration both randomly and through a 5 microns pore in response to a known chemotaxin, an increased ability to pinocytose and an increased bactericidal ability. Unless very heavily parasitized their ability to phagocytose is unaltered. Parasitized macrophages are unaltered in their ability to secrete extracellularly lysosomal enzymes, prostaglandins and lysozyme in response to known stimuli, or to kill target cells in an antibody dependent cell mediated cytotoxicity assay.
与正常巨噬细胞相比，感染墨西哥利什曼原虫无鞭毛体的巨噬细胞对已知趋化因子的随机迁移和通过5微米孔径的迁移均减少，胞饮能力增强，杀菌能力增强。除非寄生非常严重，其吞噬能力不变。在已知刺激下，寄生巨噬细胞分泌细胞外溶酶体酶、前列腺素和溶菌酶的能力，或在抗体依赖性细胞介导的细胞毒性试验中杀死靶细胞的能力均未改变。
