Imura H, Nakai Y, Nakao K, Oki S, Tanaka I, Jingami H, Yoshimasa T, Tsukada T, Ikeda Y, Suda M, Sakamoto M
J Endocrinol Invest. 1983 Apr;6(2):139-49. doi: 10.1007/BF03350587.
Group III opioid peptides are derived from proenkephalin B. The processing of this precursor peptide is still only partly understood and we still do not know how many final products come from proenkephalin B and whether Leu-enkephalin is produced from Group III peptides. However, potent biologic activity of Group III opioid peptides and existence of opiate-receptors specific for these peptides (k receptors) strongly suggest that Group III opioid peptides are not precursors of Leu-enkephalin but bioactive substances per se. Further studies should clarify details of the processing of proenkephalin B.
第三组阿片肽由前脑啡肽B衍生而来。目前对这种前体肽的加工过程仍仅部分了解，我们仍不清楚前脑啡肽B会产生多少最终产物，以及亮氨酸脑啡肽是否由第三组肽产生。然而，第三组阿片肽的强大生物活性以及针对这些肽的阿片受体（κ受体）的存在，强烈表明第三组阿片肽不是亮氨酸脑啡肽的前体，而是本身具有生物活性的物质。进一步的研究应阐明前脑啡肽B加工过程的细节。
