• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Severe anxiety induced by FG 7142, a beta-carboline ligand for benzodiazepine receptors.

作者信息

Dorow R, Horowski R, Paschelke G, Amin M

出版信息

Lancet. 1983 Jul 9;2(8341):98-9. doi: 10.1016/s0140-6736(83)90076-4.

DOI:10.1016/s0140-6736(83)90076-4
PMID:6134976
Abstract
摘要

相似文献

1
Severe anxiety induced by FG 7142, a beta-carboline ligand for benzodiazepine receptors.FG 7142（一种苯二氮䓬受体的β-咔啉配体）诱发的严重焦虑。
Lancet. 1983 Jul 9;2(8341):98-9. doi: 10.1016/s0140-6736(83)90076-4.
2
Differential effect of gamma-aminobutyric acid on benzodiazepine receptor subtypes labeled by [3H]propyl beta-carboline-3-carboxylate in rat brain.
J Pharmacol Exp Ther. 1983 Apr;225(1):132-7.
3
beta-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of beta-carboline-3-carboxylic acid.β-咔啉作为苯二氮䓬受体配体。1. β-咔啉-3-羧酸酯的合成及其与苯二氮䓬受体的相互作用
J Med Chem. 1983 Apr;26(4):499-503. doi: 10.1021/jm00358a008.
4
Interactions of ethyl-beta-carboline-3-carboxylate and Ro 15-1788 with CGS 8216 in an animal model of anxiety.
Neurosci Lett. 1983 Aug 19;39(1):91-4. doi: 10.1016/0304-3940(83)90170-2.
5
Characteristics of [3H] propyl beta-carboline-3-carboxylate binding to benzodiazepine receptors in human brain.
Res Commun Chem Pathol Pharmacol. 1984 May;44(2):199-213.
6
Enhanced binding of the convulsive ligand DMCM to high-energy irradiated benzodiazepine receptors; evidence of complex receptor structure.
Biochem Pharmacol. 1983 Jan 1;32(1):177-80. doi: 10.1016/0006-2952(83)90676-7.
7
Anxiogenic, not psychotogenic, properties of the partial inverse benzodiazepine receptor agonist FG 7142 in man.部分反向苯二氮䓬受体激动剂FG 7142在人体中具有致焦虑而非致精神病的特性。
Psychopharmacology (Berl). 2002 Jul;162(2):223-4. doi: 10.1007/s00213-002-1095-1.
8
Ethyl beta-carboline-3-carboxylate antagonises the effect of diazepam on a functional GABA receptor.
Eur J Pharmacol. 1980 Dec 19;68(4):513-4. doi: 10.1016/0014-2999(80)90430-6.
9
From the behavioral pharmacology of beta-carbolines to seizures, anxiety, and memory.从β-咔啉的行为药理学到癫痫、焦虑和记忆。
ScientificWorldJournal. 2007 Feb 19;7:204-23. doi: 10.1100/tsw.2007.48.
10
Binding of strychnocarpine and related beta-carbolines to brain receptors in vitro.马钱子碱及相关β-咔啉在体外与脑受体的结合
Eur J Pharmacol. 1992 Apr 22;214(2-3):165-8. doi: 10.1016/0014-2999(92)90114-j.

引用本文的文献

1
An unescapable looming threat paradigm for assessing anxiety-like responses in rats.用于评估大鼠类焦虑反应的无法逃避的迫在眉睫威胁范式。
Behav Brain Res. 2025 Feb 4;477:115296. doi: 10.1016/j.bbr.2024.115296. Epub 2024 Oct 18.
2
Pharmacological validation of an attention bias test for conventional broiler chickens.常规肉鸡注意偏向测试的药理学验证。
PLoS One. 2024 Apr 9;19(4):e0297715. doi: 10.1371/journal.pone.0297715. eCollection 2024.
3
β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction.
灵长类动物背外侧前额叶皮质中γ-氨基丁酸能中间神经元上的β1-肾上腺素能受体表达：在应激诱导的认知功能障碍中的潜在作用
Neurobiol Stress. 2024 Mar 15;30:100628. doi: 10.1016/j.ynstr.2024.100628. eCollection 2024 May.
4
β-Carboline (FG-7142) modulates fear but not anxiety-like behaviour in zebrafish.β-咔啉（FG-7142）调节斑马鱼的恐惧但不调节焦虑样行为。
Sci Rep. 2024 Jan 5;14(1):668. doi: 10.1038/s41598-023-51072-6.
5
A pontomesencephalic PACAPergic pathway underlying panic-like behavioral and somatic symptoms in mice.中脑中脑 PACAP 能神经通路介导小鼠的惊恐样行为和躯体症状。
Nat Neurosci. 2024 Jan;27(1):90-101. doi: 10.1038/s41593-023-01504-3. Epub 2024 Jan 4.
6
Kappa opioid receptor antagonism protects working memory performance from mild stress exposure in Rhesus macaques.κ阿片受体拮抗作用可保护恒河猴的工作记忆表现免受轻度应激暴露的影响。
Neurobiol Stress. 2022 Sep 24;21:100493. doi: 10.1016/j.ynstr.2022.100493. eCollection 2022 Nov.
7
A randomized, double-blind, placebo-controlled phase II trial to explore the effects of a GABA-α5 NAM (basmisanil) on intellectual disability associated with Down syndrome.一项旨在探索 GABA-α5 NAM（巴米沙尼）对唐氏综合征相关智力障碍影响的随机、双盲、安慰剂对照的 II 期临床试验。
J Neurodev Disord. 2022 Feb 5;14(1):10. doi: 10.1186/s11689-022-09418-0.
8
Basmisanil, a highly selective GABA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man.巴米沙尼，一种高选择性 GABA-α5 负变构调节剂：临床前药理学及在人体中功能性靶向结合的验证。
Sci Rep. 2021 Apr 8;11(1):7700. doi: 10.1038/s41598-021-87307-7.
9
FG 7142: is this validated tool to study anxiety now forgotten?FG 7142：这个用于研究焦虑的经过验证的工具现在被遗忘了吗？
J Neural Transm (Vienna). 2020 Feb;127(2):287-289. doi: 10.1007/s00702-019-02136-3. Epub 2020 Jan 11.
10
Role of KCNQ potassium channels in stress-induced deficit of working memory.KCNQ钾通道在应激诱导的工作记忆缺陷中的作用。
Neurobiol Stress. 2019 Jul 26;11:100187. doi: 10.1016/j.ynstr.2019.100187. eCollection 2019 Nov.