Dubois D, Petitcolas J, Temperville B, Klepper A, Catherine P
Clin Exp Hypertens B. 1983;2(1):41-59. doi: 10.3109/10641958309023458.
Over a period of 4 years, a team of obstetricians and nephrologists have used beta-blockers in the treatment of hypertension in high risk pregnancies. One hundred and twenty one patients (125 pregnancies) were treated with this new therapeutic approach: Acebutolol (56 cases), Pindolol (38 cases) and Atenolol (31 cases) were used. In our group of patients, 56% (70/121) had a previous record of hypertension. Treatment was started when diastolic pressure reached 90 mmHg. The mothers showed excellent tolerance and in 95% of cases blood pressure was controlled in a satisfactory manner. Three groups of new-born infants were defined. In 20 infants, the weight was less than 2.5, in 15 infants between 2.5 and 2.8 kg, and in 90 infants more than 2.8 kg. There was no evidence of low Apgar scores, bradycardia or hypotension in the infants. The importance of team management of the patient is emphasised.
在4年的时间里，一组产科医生和肾病学家使用β受体阻滞剂治疗高危妊娠的高血压。121名患者（125次妊娠）接受了这种新的治疗方法：使用了醋丁洛尔（56例）、吲哚洛尔（38例）和阿替洛尔（31例）。在我们的患者组中，56%（70/121）有高血压病史。当舒张压达到90 mmHg时开始治疗。母亲们耐受性良好，95%的病例血压得到满意控制。定义了三组新生儿。20名婴儿体重低于2.5千克，15名婴儿体重在2.5至2.8千克之间，90名婴儿体重超过2.8千克。婴儿中没有低阿氏评分、心动过缓或低血压的迹象。强调了对患者进行团队管理的重要性。
