Baktir G, Fisch H U, Huguenin P, Bircher J
Clin Pharmacol Ther. 1983 Aug;34(2):195-201. doi: 10.1038/clpt.1983.152.
Triazolam was used to study the plasma concentration-effect relationship of a benzodiazepine because it has a very short plasma t1/2. A standard hypnotic dose of 0.25 mg was given by mouth to six healthy subjects, and blood samples were drawn when the subjects had to perform a battery of psychologic tests. Only the digit-symbol substitution test, the card-sorting test according to numbers, and the visual analog scale (energetic-lethargic) gave significant results. Analysis of the concentration-effect relationship in individuals indicated a wide scatter of the data. Mean values revealed a trend for a learning effect in the card-sorting test. The results are consistent with the hypothesis that triazolam is well suited for a study of concentration-effect relationships, but better psychologic tests would be desirable.
三唑仑被用于研究苯二氮䓬类药物的血浆浓度-效应关系，因为它的血浆半衰期非常短。给6名健康受试者口服0.25mg的标准催眠剂量，当受试者必须进行一系列心理测试时采集血样。只有数字符号替换测试、按数字分类的卡片分类测试以及视觉模拟量表（精力充沛-无精打采）给出了显著结果。个体浓度-效应关系分析表明数据分散性很大。平均值显示卡片分类测试中有学习效应的趋势。结果与以下假设一致，即三唑仑非常适合用于浓度-效应关系的研究，但需要更好的心理测试。
