Robertson E N, Fragen R J, Booij L H, van Egmond J, Crul J F
Br J Anaesth. 1983 Aug;55(8):723-8. doi: 10.1093/bja/55.8.723.
The effects of a bolus injection of diisopropyl phenol 2 mg kg-1 i.v. and an infusion (150 micrograms kg-1 min-1 for 30 min and 75 micrograms kg-1 min-1 thereafter) on the pharmacodynamics and dose-response curves of atracurium and vecuronium were studied in 52 healthy (ASA I or II) patients. Under anaesthesia with diisopropyl phenol, the cumulative dose-response curves of both myoneural blocking drugs were shifted to the left when compared with previously reported results. However, there was no clinically significant change in the pharmacodynamics of either drug after the bolus injection of the blocking drug. Diisopropyl phenol 2 mg kg-1 i.v. administered during steady-state infusions of vecuronium and atracurium increased the depth of the constant neuromuscular blockade. When diisopropyl phenol alone was given to four patients there was no change in the twitch height. These results show that diisopropyl phenol, given according to the regimen in this study, potentiates both of the neuromuscular blockers studied but does not prolong the duration of action of either drug. During the infusion of diisopropyl phenol, vecuronium was found to be five times more potent, to have a more rapid onset time, and to be shorter acting than an equipotent dose of atracurium.
在52例健康（ASA I或II级）患者中，研究了静脉注射2 mg/kg异丙酚推注剂量以及输注（先以150μg/kg·min输注30分钟，随后以75μg/kg·min输注）对阿曲库铵和维库溴铵药效学及剂量反应曲线的影响。在异丙酚麻醉下，与先前报道的结果相比，两种肌松药物的累积剂量反应曲线均向左移动。然而，在注射肌松药物推注剂量后，两种药物的药效学均未出现具有临床意义的变化。在维库溴铵和阿曲库铵稳态输注期间静脉注射2 mg/kg异丙酚，可增加恒定神经肌肉阻滞的深度。当仅对4例患者给予异丙酚时，颤搐高度无变化。这些结果表明，按照本研究中的方案给予异丙酚，可增强所研究的两种神经肌肉阻滞剂的作用，但不会延长任何一种药物的作用持续时间。在输注异丙酚期间，发现维库溴铵的效价是等效剂量阿曲库铵的5倍，起效更快，作用时间更短。
