Wilson C G, Olejnik O, Hardy J G
J Pharm Pharmacol. 1983 Jul;35(7):451-4. doi: 10.1111/j.2042-7158.1983.tb04320.x.
A method for monitoring the ocular distribution of solutions for ophthalmic use was developed using the technique of gamma scintigraphy. This method was used to monitor the effects of polyvinyl alcohol on the precorneal drainage of [99mTc]pertechnetate in the rabbit. The rate of drainage of solutions decreased on addition of PVA and precorneal residence of the marker was significantly prolonged, compared with saline controls, at a PVA concentration of 5% W/V. Increases in the activity in the inner canthal region mirrored the decrease in corneal counts. The method has a more general application for the study of ophthalmic formulations and devices in larger mammals and in man.
利用γ闪烁扫描技术开发了一种监测眼科用溶液眼部分布的方法。该方法用于监测聚乙烯醇对兔眼角膜前[99mTc]高锝酸盐引流的影响。与生理盐水对照相比，添加聚乙烯醇后溶液的引流速率降低，在聚乙烯醇浓度为5%（重量/体积）时，标记物在角膜前的停留时间显著延长。内眦区域活性的增加反映了角膜计数的减少。该方法在研究大型哺乳动物和人类的眼科制剂及器械方面具有更广泛的应用。
