健康受试者眼用软膏角膜前滞留情况的评估。
Assessment of the precorneal residence of an ophthalmic ointment in healthy subjects.
作者信息
Greaves J L, Wilson C G, Birmingham A T
机构信息
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham.
出版信息
Br J Clin Pharmacol. 1993 Feb;35(2):188-92.
Abstract
- The precorneal residence of an ophthalmic ointment radiolabelled by inclusion of technetium-99m tin colloid was assessed in seven volunteer subjects using the technique of gamma scintigraphy and compared with a solution of 0.3% w/v hydroxypropylmethylcellulose, (HPMC) radiolabelled by inclusion of technetium-99m diethylenetriaminepentaacetic acid in the same subjects. 2. The mean half-times (+/- s.d.) of corneal residence were 6490 +/- 5404 s (108 min) for the ointment and 13 +/- 24 s for the 0.3% w/v HPMC solution (P < 0.01). 3. The area-under-curve value (AUC(0,540 s)), which reflects the total residence time of the preparation on the ocular surface, was calculated for each vehicle in each subject. The mean (+/- s.d.) AUC(0,540 s) value for the ointment was 42170 (+/- 5032)% s and for the 0.3% w/v HPMC solution it was 8394 (+/- 4641)% s (P < 0.01).
摘要
- 采用γ闪烁显像技术，在7名志愿者受试者中评估了含有锝-99m锡胶体的放射性标记眼药膏在角膜前的停留情况，并与在相同受试者中含有锝-99m二乙三胺五乙酸的0.3% w/v羟丙基甲基纤维素（HPMC）溶液进行了比较。2. 眼药膏角膜停留的平均半衰期（±标准差）为6490±5404秒（108分钟），0.3% w/v HPMC溶液为13±24秒（P<0.01）。3. 计算了每个受试者每种制剂的曲线下面积值（AUC(0,540 s)），其反映了制剂在眼表的总停留时间。眼药膏的平均（±标准差）AUC(0,540 s)值为42170（±5032）%·秒，0.3% w/v HPMC溶液为8394（±4641）%·秒（P<0.01）。
相似文献
1
Assessment of the precorneal residence of an ophthalmic ointment in healthy subjects.健康受试者眼用软膏角膜前滞留情况的评估。
Br J Clin Pharmacol. 1993 Feb;35(2):188-92.
2
Ocular surface residence times of artificial tear solutions.人工泪液制剂在眼表的停留时间。
Cornea. 1992 Jul;11(4):288-93. doi: 10.1097/00003226-199207000-00003.
3
A comparison of the precorneal residence of an artificial tear preparation in patients with keratoconjunctivitis sicca and normal volunteer subjects using gamma scintigraphy.使用γ闪烁扫描术比较人工泪液制剂在干眼症患者和正常志愿者角膜前的停留情况。
Acta Ophthalmol (Copenh). 1991 Aug;69(4):432-6. doi: 10.1111/j.1755-3768.1991.tb02018.x.
4
Gamma scintigraphic comparison of eyedrops containing pilocarpine in healthy volunteers.
J Ocul Pharmacol Ther. 1996 Winter;12(4):481-8. doi: 10.1089/jop.1996.12.481.
5
The disintegration behaviour of capsules in fed subjects: a comparison of hypromellose (carrageenan) capsules and standard gelatin capsules.口服给予受试物后胶囊的崩解行为：羟丙甲纤维素（卡拉胶）胶囊与标准明胶胶囊的比较。
Int J Pharm. 2012 Mar 15;424(1-2):40-3. doi: 10.1016/j.ijpharm.2011.12.034. Epub 2011 Dec 28.
6
A comparison of the effect of viscosity on the precorneal residence of solutions in rabbit and man.兔与人中溶液粘度对角膜前滞留效应的比较。
J Pharm Pharmacol. 1986 Jun;38(6):463-6. doi: 10.1111/j.2042-7158.1986.tb04611.x.
7
Scintigraphic assessment of an ophthalmic gelling vehicle in man and rabbit.人及兔眼用凝胶制剂的闪烁扫描评估
Curr Eye Res. 1990 May;9(5):415-20. doi: 10.3109/02713689008999606.
8
Ocular contact time of a carbomer gel (GelTears) in humans.卡波姆凝胶（凝胶泪液）在人体中的眼接触时间。
Br J Ophthalmol. 1998 Oct;82(10):1131-4. doi: 10.1136/bjo.82.10.1131.
9
In-vitro and in-vivo erosion profiles of hydroxypropylmethylcellulose (HPMC) matrix tablets.羟丙甲纤维素（HPMC）基质片的体外和体内侵蚀曲线。
J Control Release. 2010 Oct 1;147(1):70-5. doi: 10.1016/j.jconrel.2010.06.015. Epub 2010 Jun 23.
10
Scintigraphic studies on the corneal residence of a New Ophthalmic Delivery System (NODS): rate of clearance of a soluble marker in relation to duration of pharmacological action of pilocarpine.新型眼科给药系统（NODS）角膜滞留的闪烁扫描研究：可溶性标记物清除率与毛果芸香碱药理作用持续时间的关系。
Br J Clin Pharmacol. 1992 Jun;33(6):603-9. doi: 10.1111/j.1365-2125.1992.tb04088.x.
引用本文的文献
1
Scanning Electron Microscopy (SEM) Evaluation of the Ultrastructural Effects on Conjunctival Epithelial Cells of a New Multiple-Action Artificial Tear Containing Cross-Linked Hyaluronic Acid, Cationic Liposomes and Trehalose.扫描电子显微镜（SEM）评估一种新型多效人工泪液对结膜上皮细胞超微结构的影响，该人工泪液含有交联透明质酸、阳离子脂质体和海藻糖。
Biomedicines. 2024 Aug 23;12(9):1945. doi: 10.3390/biomedicines12091945.
2
Recent updates on ocular disease management with ophthalmic ointments.眼部软膏在眼病治疗管理方面的最新进展。
Ther Deliv. 2024;15(6):463-480. doi: 10.1080/20415990.2024.2346047. Epub 2024 Jun 11.
3
Effect of Particle Size and Viscosity of Suspensions on Topical Ocular Bioavailability of Budesonide, a Corticosteroid.混悬剂的粒径和黏度对皮质类固醇布地奈德眼部局部生物利用度的影响。
J Ocul Pharmacol Ther. 2020 Jul/Aug;36(6):404-409. doi: 10.1089/jop.2019.0150. Epub 2020 Jul 14.
4
Ocular Biodistribution Studies using Molecular Imaging.使用分子成像技术的眼部生物分布研究
Pharmaceutics. 2019 May 16;11(5):237. doi: 10.3390/pharmaceutics11050237.
5
Perspectives on Physicochemical and In Vitro Profiling of Ophthalmic Ointments.眼科软膏的物理化学和体外分析概述。
Pharm Res. 2018 Oct 15;35(12):234. doi: 10.1007/s11095-018-2513-3.
6
Development of Methodologies to Investigate Binding by Sodium Hyaluronate in Eye Drops to Corneal Surfaces.研究滴眼液中透明质酸钠与角膜表面结合的方法的开发
Open Ophthalmol J. 2018 Jul 31;12:226-240. doi: 10.2174/1874364101812010226. eCollection 2018.
7
Relevance of Lipid-Based Products in the Management of Dry Eye Disease.基于脂质的产品在干眼症管理中的相关性。
J Ocul Pharmacol Ther. 2017 Nov;33(9):647-661. doi: 10.1089/jop.2017.0052. Epub 2017 Sep 28.
8
In vitro release testing method development for ophthalmic ointments.眼用软膏的体外释放测试方法开发
Int J Pharm. 2017 Jun 30;526(1-2):145-156. doi: 10.1016/j.ijpharm.2017.04.075. Epub 2017 Apr 29.
9
Physicochemical attributes and dissolution testing of ophthalmic ointments.眼用软膏的物理化学属性及溶出度测试
Int J Pharm. 2017 May 15;523(1):310-319. doi: 10.1016/j.ijpharm.2017.03.039. Epub 2017 Mar 24.
10
Time course of changes in ocular wavefront aberration after administration of eye ointment.眼药膏给药后眼波前像差变化的时间过程。
Eye (Lond). 2012 Oct;26(10):1310-7. doi: 10.1038/eye.2012.142. Epub 2012 Jul 20.
本文引用的文献
1
Topically applied pilocarpine. Human pupillary response as a function of drop size.局部应用毛果芸香碱。人瞳孔反应与滴眼液大小的关系。
Arch Ophthalmol. 1980 Jan;98(1):112-5. doi: 10.1001/archopht.1980.01020030114010.
2
Pharmacokinetics of topically applied ophthalmic drugs.局部应用眼科药物的药代动力学。
Surv Ophthalmol. 1982 Jan-Feb;26(4):207-18. doi: 10.1016/0039-6257(82)90081-9.
3
Direct physical demonstration of oily layer on tear film surface.泪膜表面油性层的直接物理演示。
Am J Ophthalmol. 1972 Jan;73(1):132-4. doi: 10.1016/0002-9394(72)90315-7.
4
Scintigraphic assessment of an ophthalmic gelling vehicle in man and rabbit.人及兔眼用凝胶制剂的闪烁扫描评估
Curr Eye Res. 1990 May;9(5):415-20. doi: 10.3109/02713689008999606.
5
A comparison of the precorneal residence of an artificial tear preparation in patients with keratoconjunctivitis sicca and normal volunteer subjects using gamma scintigraphy.使用γ闪烁扫描术比较人工泪液制剂在干眼症患者和正常志愿者角膜前的停留情况。
Acta Ophthalmol (Copenh). 1991 Aug;69(4):432-6. doi: 10.1111/j.1755-3768.1991.tb02018.x.
6
Effects of drug vehicles on ocular uptake of tetracycline.药物载体对四环素眼部摄取的影响。
Am J Ophthalmol. 1975 Jul;80(1):133-8. doi: 10.1016/0002-9394(75)90883-1.
7
Effects of drug vehicles on ocular contact time.药物载体对眼部接触时间的影响。
Arch Ophthalmol. 1975 Jan;93(1):42-5. doi: 10.1001/archopht.1975.01010020046008.
8
Effect of drug vehicle on human ocular retention of topically applied tetracycline.药物载体对局部应用四环素在人眼内滞留的影响。
Am J Ophthalmol. 1976 Feb;81(2):151-6. doi: 10.1016/0002-9394(76)90726-1.
9
Ocular bioavailability and systemic loss of topically applied ophthalmic drugs.局部应用眼科药物的眼部生物利用度和全身损失。
Am J Ophthalmol. 1978 Feb;85(2):225-9. doi: 10.1016/s0002-9394(14)75953-7.
Zotero 插件