酒精滥用和空肠回肠旁路术后肝炎的发病机制。
The pathogenesis of hepatitis in alcohol abuse and jejunoileal bypass.
作者信息
Barry R E
出版信息
Lancet. 1983 Aug 27;2(8348):489-90. doi: 10.1016/s0140-6736(83)90515-9.
PMID:6136648
Abstract
Acetaldehyde, produced in excessive amounts in alcohol abuse or after jejunoileal bypass, binds to hepatocyte plasma membranes by way of formation of an intermediate Schiff's base. This binding has no effect on cellular metabolism or membrane function but causes physical changes in membrane properties which activate the complement cascade and this results in hepatocellular damage.
摘要
乙醛在酒精滥用或空肠回肠旁路术后过量产生，通过形成中间席夫碱与肝细胞质膜结合。这种结合对细胞代谢或膜功能没有影响，但会引起膜特性的物理变化，从而激活补体级联反应，进而导致肝细胞损伤。
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引用本文的文献
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Alcoholic liver disease in the 1980s.20世纪80年代的酒精性肝病。
Br Med J (Clin Res Ed). 1983 Dec 17;287(6408):1819-21. doi: 10.1136/bmj.287.6408.1819.
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Acetaldehyde alone may initiate hepatocellular damage in acute alcoholic liver disease.仅乙醛就可能在急性酒精性肝病中引发肝细胞损伤。
Gut. 1985 Oct;26(10):1065-9. doi: 10.1136/gut.26.10.1065.
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