一项双盲研究，旨在比较阿莫西林或头孢拉定对共生菌群中抗生素耐药性的选择作用。

Double-blind study to compare the selection of antibiotic resistance by amoxycillin or cephradine in the commensal flora.

作者信息

Lacey R W, Lord V L, Howson G L, Luxton D E, Trotter I S

出版信息

Lancet. 1983 Sep 3;2(8349):529-32. doi: 10.1016/s0140-6736(83)90566-4.

Abstract

Elderly patients with acute urinary infections were treated in a double-blind study with either amoxycillin or cephradine. In 52 patients who had received amoxycillin for one week about a third of all intestinal Escherichia coli were highly resistant to amoxycillin, and many were resistant to tetracycline, trimethoprim, or chloramphenicol. Cephradine selected less resistance. At a week after completion of chemotherapy, cephradine-resistant E coli were replaced by sensitive cultures at a greater frequency than were amoxycillin-resistant E coli. Neither antibiotic altered the skin flora. Amoxycillin, but not cephradine, selected for Enterobacteriaceae in the saliva. The propensity of amoxycillin to select resistance in E coli will limit its usefulness in treating urinary infections.

摘要

在一项双盲研究中，使用阿莫西林或头孢拉定对老年急性尿路感染患者进行治疗。在52名接受了一周阿莫西林治疗的患者中，所有肠道大肠杆菌约有三分之一对阿莫西林高度耐药，许多对四环素、甲氧苄啶或氯霉素也耐药。头孢拉定产生的耐药性较少。化疗结束一周后，头孢拉定耐药的大肠杆菌被敏感培养物取代的频率高于阿莫西林耐药的大肠杆菌。两种抗生素均未改变皮肤菌群。阿莫西林而非头孢拉定在唾液中选择了肠杆菌科细菌。阿莫西林在大肠杆菌中产生耐药性的倾向将限制其在治疗尿路感染中的效用。