单剂量氨苄西林治疗淋病后大肠杆菌产生的耐药性。
Resistance in Escherichia coli after single dose ampicillin to treat gonorrhoea.
作者信息
Mulcahy F M, Lacey C J, Barr K, Lacey R W
出版信息
Genitourin Med. 1986 Jun;62(3):166-9. doi: 10.1136/sti.62.3.166.
Patients with uncomplicated gonorrhoea were treated with a single dose of either ampicillin 3 g orally or procaine penicillin 2.4 MIU by injection, both with probenecid 1 g orally. The proportion of faecal Escherichia coli resistant to ampicillin before and a week after treatment was assessed. Of 55 patients treated with ampicillin who initially possessed sensitive flora, 25 (45.5%) became colonised subsequently by resistant E coli. Resistance to ampicillin, together with resistance to some other antimicrobials, was transferable in vitro. Penicillin, however, selected resistant E coli in only four (14.3%) out of 28 patients with initially sensitive flora. There was no difference in therapeutic response between the two agents. Intramuscular penicillin appeared to offer appreciably greater microbiological benefits than oral ampicillin in treating gonorrhoea.
单纯性淋病患者接受单次口服3克氨苄西林或注射240万国际单位普鲁卡因青霉素治疗，两者均联合口服1克丙磺舒。评估治疗前及治疗一周后粪便中对氨苄西林耐药的大肠杆菌比例。在55例最初拥有敏感菌群并接受氨苄西林治疗的患者中，25例（45.5%）随后被耐药大肠杆菌定植。对氨苄西林的耐药性以及对其他一些抗菌药物的耐药性在体外是可转移的。然而，在28例最初拥有敏感菌群的患者中，只有4例（14.3%）因青霉素治疗而出现耐药大肠杆菌。两种药物的治疗反应没有差异。在治疗淋病方面，肌内注射青霉素似乎比口服氨苄西林具有明显更大的微生物学益处。
Zotero 插件