Mancia G, Bertinieri G, Grassi G, Parati G, Pomidossi G, Ferrari A, Gregorini L, Zanchetti A
Lancet. 1983 Sep 24;2(8352):695-8. doi: 10.1016/s0140-6736(83)92244-4.
Changes in blood pressure in 10 or 15 min periods during which a doctor repeatedly measured blood pressure by the cuff method were monitored by a continuous intra-arterial recorder. In almost all the 48 normotensive and hypertensive subjects tested the doctor's arrival at the bedside induced immediate rises in systolic and diastolic blood pressures peaking within 1 to 4 min (mean 26.7 +/- 2.3 mm Hg and 14.9 +/- 1.6 mm Hg above pre-visit values). There were large differences between individuals in the peak response (range, 4--75 mm Hg systolic and 1--36 mm Hg diastolic) unrelated to age, sex, baseline blood pressure, or blood-pressure variability. There was concomitant tachycardia (average peak response 15.9 +/- 1.5 beats/min, range 4--45 beats/min) which was only slightly correlated with the blood-pressure rise. After the peak response blood pressure declined and at the end of the visit was only slightly above the pre-visit level. A second visit by the same doctor did not change the average size of the early pressor response or the slope of its subsequent decline.
在10或15分钟的时间段内，医生通过袖带法反复测量血压，同时用连续动脉内记录仪监测血压变化。在接受测试的48名血压正常和高血压受试者中，几乎所有人在医生到达床边时，收缩压和舒张压立即升高，在1至4分钟内达到峰值（平均比就诊前值高26.7±2.3毫米汞柱和14.9±1.6毫米汞柱）。个体之间的峰值反应存在很大差异（范围为收缩压4 - 75毫米汞柱和舒张压1 - 36毫米汞柱），与年龄、性别、基线血压或血压变异性无关。同时伴有心动过速（平均峰值反应为15.9±1.5次/分钟，范围为4 - 45次/分钟），且与血压升高仅存在微弱关联。在峰值反应后血压下降，就诊结束时仅略高于就诊前水平。同一位医生的第二次就诊并未改变早期升压反应的平均幅度或其随后下降的斜率。
