Power D A, Catto G R, Mason R J, MacLeod A M, Stewart G M, Stewart K N, Shewan W G
Lancet. 1983 Sep 24;2(8352):701-4. doi: 10.1016/s0140-6736(83)92246-8.
Non-cytotoxic antibodies to paternal B lymphocytes were detected in sera from 11 of 11 multiparous women and from 11 of 16 normal primigravidae during the first trimester of pregnancy. These antibodies were not, however, detected in sera from 9 of 10 women of comparable gestation at the time of spontaneous abortion. By means of a rosette inhibition assay, the difference in antibody activity between the primigravidae (mean 37.9 +/- 19%, median 36.5%) and the women subject to spontaneous abortion (mean 7.3 +/- 11.6%, median 0%) was statistically significant. This antibody activity was not directed to the known HLA specificities (HLA--A, B, C, or DR), but linkage to the HLA gene complex was suggested by family studies. These results provide evidence for an HLA-linked antigen system not defined by conventional tissue-typing techniques. Fetomaternal disparity at this antigenic site may be important for successful pregnancy.
在11名经产妇以及16名正常初产妇妊娠早期的血清中，检测到了针对父本B淋巴细胞的无细胞毒性抗体。然而，在10名处于相同孕周的自然流产女性中，有9名女性的血清中未检测到此类抗体。通过玫瑰花结抑制试验，初产妇（平均37.9 +/- 19%，中位数36.5%）与自然流产女性（平均7.3 +/- 11.6%，中位数0%）之间的抗体活性差异具有统计学意义。这种抗体活性并非针对已知的HLA特异性抗原（HLA - A、B、C或DR），但家族研究表明其与HLA基因复合体存在连锁关系。这些结果为一种未通过传统组织分型技术定义的HLA连锁抗原系统提供了证据。在这个抗原位点上的母胎差异可能对成功妊娠至关重要。
