Zuccarini O, Sensi M, Gargiulo P, Pozzilli P, Tiberti C, Pachi A, Fallucca F
Diabetologia. 1985 Feb;28(2):95-8. doi: 10.1007/BF00279923.
The presence of Fc-receptor-blocking factors in the sera of normal and insulin-dependent diabetic pregnant women was investigated by means of an antibody-dependent cell-mediated cytotoxicity assay. Sera from normal pregnant women induced a significant depression of antibody dependent cell-mediated cytotoxicity when compared with sera from normal and diabetic non-pregnant women (p less than 0.0001; p less than 0.002, respectively). The effect of sera from diabetic pregnant women, however, was not different from that observed with sera from normal and diabetic non-pregnant women. Thus, we confirm the presence of Fc-receptor-blocking factors in the sera of normal pregnant women. The higher cytotoxicity levels measured in the presence of sera from pregnant women with insulin-dependent diabetes suggests that the titres of such factors are reduced in this condition.
采用抗体依赖细胞介导的细胞毒性试验，对正常孕妇和胰岛素依赖型糖尿病孕妇血清中Fc受体阻断因子的存在情况进行了研究。与正常非孕妇和糖尿病非孕妇的血清相比，正常孕妇的血清可显著降低抗体依赖细胞介导的细胞毒性（分别为p<0.0001；p<0.002）。然而，糖尿病孕妇血清的作用与正常非孕妇和糖尿病非孕妇血清所观察到的作用并无差异。因此，我们证实正常孕妇血清中存在Fc受体阻断因子。在胰岛素依赖型糖尿病孕妇血清存在的情况下测得的较高细胞毒性水平表明，这种因子的滴度在这种情况下会降低。
