细针肾内测压法：环孢素治疗的肾移植受者排斥反应的一种新检测方法。

Fine-needle intrarenal manometry: a new test for rejection in cyclosporin-treated recipients of kidney transplants.

作者信息

Salaman J R, Griffin P J

出版信息

Lancet. 1983 Sep 24;2(8352):709-11. doi: 10.1016/s0140-6736(83)92249-3.

Abstract

Intrarenal pressure was measured in kidney-transplant recipients in an attempt to differentiate between graft rejection and cyclosporin nephrotoxicity. Intrarenal pressure was measured directly through a fine needle inserted into the kidney and connected to a manometer. Blood cyclosporin levels were monitored regularly, and renal biopsy specimens were obtained whenever renal function deteriorated. 32 recipients of renal allografts were studied 1 to 270 days after transplantation. 129 pressure readings were obtained during normal renal function, rejection, nephrotoxicity, and acute tubular necrosis (ATN). Rejection but not toxicity or ATN caused a highly significant rise in intrarenal pressure. No complications were encountered apart from transient haematuria in 1 patient. This simple test may therefore be of value in monitoring renal-transplant patients who are receiving cyclosporin.

摘要

为了区分移植肾排斥反应和环孢素肾毒性，对肾移植受者的肾内压进行了测量。通过插入肾脏并连接到压力计的细针直接测量肾内压。定期监测血中环孢素水平，每当肾功能恶化时获取肾活检标本。对32例肾移植受者在移植后1至270天进行了研究。在肾功能正常、排斥反应、肾毒性和急性肾小管坏死（ATN）期间获得了129次压力读数。排斥反应而非毒性或ATN导致肾内压显著升高。除1例患者出现短暂血尿外，未遇到其他并发症。因此，这项简单的检测可能对监测接受环孢素治疗的肾移植患者有价值。