Ziegler G, Ludwig L, Klotz U
Pharmacopsychiatria. 1983 May;16(3):71-6. doi: 10.1055/s-2007-1017452.
In the past, pharmacokinetics of benzodiazepines have been extensively described. However, knowledge about relationships between their plasma levels and pharmacodynamic effects are scanty. Therefore, we investigated under several experimental conditions the disposition and the psychological response of the short acting midazolam (single dose 0,075 mg/kg i.v. and 15 mg po) and of the moderate long acting oxazepam (30 mg/die for 5 days). Psychological and psychomotoric effects were evaluated by analogue scales (sedation index), d-2 letter cancellation test, reaction time, critical flicker fusion frequency and adjective mood list. In general, good correlations were found between those tests and plasma levels, especially for midazolam. Analogue scales and reaction-time proved to be most useful in our "effect-kinetic" approach.
过去，苯二氮䓬类药物的药代动力学已得到广泛描述。然而，关于其血浆水平与药效学效应之间关系的了解却很少。因此，我们在几种实验条件下研究了短效咪达唑仑（静脉注射单剂量0.075mg/kg和口服15mg）和中长效奥沙西泮（每日30mg，共5天）的处置情况及其心理反应。通过模拟量表（镇静指数）、d-2字母划消试验、反应时间、临界闪烁融合频率和形容词情绪列表来评估心理和精神运动效应。总体而言，在这些测试与血浆水平之间发现了良好的相关性，尤其是对于咪达唑仑。模拟量表和反应时间在我们的“效应动力学”方法中被证明是最有用的。
