卡马西平的生化效应：与其在情感性疾病中的作用机制的关系

Biochemical effects of carbamazepine: relationship to its mechanisms of action in affective illness.

作者信息

Post R M, Uhde T W, Rubinow D R, Ballenger J C, Gold P W

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(2-3):263-71. doi: 10.1016/0278-5846(83)90116-1.

Abstract

Carbamazepine has a unique spectrum of clinical efficacy in paroxysmal pain syndromes and epilepsy, as well as in affective illness. Evidence of its therapeutic effects in lithium-resistant manic-depressive illness and schizoaffective illness is reviewed. The biochemical effects of carbamazepine as they might be related to either its anticonvulsant or psychotropic properties are presented and discussed. Carbamazepine alters classical neurotransmitter and second messenger systems, as well as a variety of neuropeptides which could relate to mechanisms of action or side effects. Comparison and contrast of the biological effects of carbamazepine with classical treatment agents, such as lithium carbonate, tricyclic antidepressants, and neuroleptics may help elucidate mechanisms underlying the pathophysiology of the mood disorders.

摘要

卡马西平在阵发性疼痛综合征、癫痫以及情感性疾病方面具有独特的临床疗效谱。本文回顾了其在锂盐抵抗性躁狂抑郁症和分裂情感性疾病中的治疗效果证据。阐述并讨论了卡马西平的生化效应，这些效应可能与其抗惊厥或精神otropic特性相关。卡马西平会改变经典神经递质和第二信使系统，以及多种可能与作用机制或副作用相关的神经肽。将卡马西平的生物学效应与传统治疗药物，如碳酸锂、三环类抗抑郁药和抗精神病药物进行比较和对比，可能有助于阐明心境障碍病理生理学的潜在机制。