Yudkoff M, Nissim I, Kim S, Pleasure D, Hummeler K, Segal S
Biochem Biophys Res Commun. 1983 Aug 30;115(1):174-9. doi: 10.1016/0006-291x(83)90985-3.
Approximately 26.0% of the [15N] glutamate and [alpha 15N] glutamine formed in organotypic cerebellar explants was derived from [15N] leucine. Approximately 14.0% of the 15NH3 and [amide 15N] glutamine synthesized came from leucine nitrogen. Another 4.0% of the alpha nitrogen of both glutamate and glutamine was derived from [15N] valine. These results suggest that branched-chain amino acids, particularly leucine, may be important for the synthesis of glutamic acid by the brain.
