Gundersen C B, Miledi R, Parker I
Proc R Soc Lond B Biol Sci. 1983 Aug 22;219(1214):103-9. doi: 10.1098/rspb.1983.0062.
When poly(A)+-mRNA, extracted from rat brain, was injected into Xenopus laevis oocytes, it induced the appearance of serotonin receptors in the oocyte membrane. Application of serotonin to injected oocytes elicited, after a long delay, oscillations in membrane current. The equilibrium potential of this current corresponded with the chloride equilibrium potential. It appears that rat brain mRNA encodes the translation of serotonin receptors into the oocyte membrane. The combination of serotonin with these receptors leads to the opening of membrane channels.
当从大鼠脑中提取的多聚腺苷酸（poly(A)）+ -mRNA 注射到非洲爪蟾卵母细胞中时，它诱导了卵母细胞膜中血清素受体的出现。将血清素应用于注射后的卵母细胞，经过长时间延迟后引发了膜电流振荡。该电流的平衡电位与氯离子平衡电位相对应。似乎大鼠脑 mRNA 编码了血清素受体在卵母细胞膜中的翻译。血清素与这些受体的结合导致膜通道开放。
