Sheehan N J, Slavin B M, Kind P R, Mathews J A
Ann Rheum Dis. 1983 Oct;42(5):563-5. doi: 10.1136/ard.42.5.563.
Raised serum alkaline phosphatase (AP) levels were found in 13 of 76 patients (17%) with ankylosing spondylitis (AS), and 11 of these 13 underwent further investigation to determine the origin of the increased enzyme activity. Three had levels within the normal reference range on re-estimation, and, of the remaining 8, AP isoenzyme studies indicated an increased liver fraction in 6. Serum gamma-glutamyl transpeptidase (GGT) was raised in only 3 patients. Increased AP activity did not appear to be directly related to disease activity or to drug therapy. These findings confirm the occurrence of increased serum AP activity in AS but challenge a previously reported suggestion that bone is the source of the increased enzyme.
在76例强直性脊柱炎（AS）患者中，有13例（17%）血清碱性磷酸酶（AP）水平升高，这13例中的11例接受了进一步检查以确定酶活性增加的来源。重新检测时，3例患者的水平在正常参考范围内，其余8例中，AP同工酶研究表明6例患者的肝脏部分升高。仅3例患者血清γ-谷氨酰转肽酶（GGT）升高。AP活性增加似乎与疾病活动或药物治疗无直接关系。这些发现证实了AS患者血清AP活性增加的情况，但对先前报道的认为骨骼是酶增加来源的观点提出了质疑。
