Chang T M, Barre P
Lancet. 1983 Nov 5;2(8358):1051-3. doi: 10.1016/s0140-6736(83)91039-5.
An intravenous infusion of desferrioxamine (3 g) was given to 17 chronic renal failure patients stabilised on standard haemodialysis. Aluminium clearance 48 h after desferrioxamine was 65.3 +/- 11.0 ml/min for 'Dialaid 4000' with 70 g coated charcoal haemoperfusion system; 44.6 +/- 13.7 ml/min for 'Rhondial 75' with polyacrylonitrate membrane; 35.8 +/- 11.0 ml/min for 'Monitral' with polyacrylonitrate membrane; and 4.0 +/- 17.8 ml/min for haemodialysers with a 'Cupraphane' membrane. None of these 4 systems removed any aluminium in the absence of desferrioxamine in the same patients. Even at a desferrioxamine concentration of 40 mg/dl, coated activated charcoal (CAC) was not saturated. CAC did not absorb ferric ions in vitro. But when 40 mg/dl of desferrioxamine was present CAC absorbed increasing concentrations of ferric ions in a linear fashion.
对17名通过标准血液透析病情稳定的慢性肾衰竭患者静脉输注去铁胺（3克）。去铁胺给药48小时后，使用含70克包膜活性炭血液灌流系统的“Dialaid 4000”时铝清除率为65.3±11.0毫升/分钟；使用聚丙烯腈膜的“Rhondial 75”时为44.6±13.7毫升/分钟；使用聚丙烯腈膜的“Monitral”时为35.8±11.0毫升/分钟；使用“铜仿膜”的血液透析器时为4.0±17.8毫升/分钟。在相同患者中，若没有去铁胺，这4种系统均不能清除任何铝。即使去铁胺浓度为40毫克/分升，包膜活性炭（CAC）也未饱和。体外实验中，CAC不吸收铁离子。但当存在40毫克/分升的去铁胺时，CAC以线性方式吸收浓度不断增加的铁离子。
