Hutchcroft B J, Moore E G, Orange R P
J Allergy Clin Immunol. 1979 Jun;63(6):376-82. doi: 10.1016/0091-6749(79)90209-4.
The effects of H1 and H2 receptor anatagonists on models of allergic reactions in monkey skin have been studied. Intradermal histamine is markedly inhibited by H1 receptor antagonists but not by H2 receptor antagonists in the doses used. However, the combination of both receptor antagonists gives greater inhibition than that seen with H1 receptor blockade alone. Reverse-type anaphylaxis is also markedly inhibited by H1 but not H2 receptor antagonists. Passive cutaneous anaphylaxis (PCA) is likewise inhibited by H1 receptor antagonism, but not by H2 receptor antagonism. The combination of the two inhibitors leads to a complete inhibition of this PCA response. The data suggest that the addition of an H2 receptor antagonist may potentiate the effect of H1 blockade alone.
已对H1和H2受体拮抗剂对猴皮肤过敏反应模型的作用进行了研究。在所用剂量下，H1受体拮抗剂可显著抑制皮内组胺，但H2受体拮抗剂则无此作用。然而，两种受体拮抗剂联合使用比单独使用H1受体阻滞剂产生的抑制作用更强。H1受体拮抗剂可显著抑制反向型过敏反应，而H2受体拮抗剂则无此作用。被动皮肤过敏反应（PCA）同样可被H1受体拮抗作用抑制，但不能被H2受体拮抗作用抑制。两种抑制剂联合使用可导致该PCA反应完全被抑制。数据表明，添加H2受体拮抗剂可能会增强单独使用H1阻滞剂的效果。
