Kaneko M, Saito S, Tsuchida Y, Nakajo T, Akiyama H
Z Kinderchir. 1983 Oct;38(5):345-9. doi: 10.1055/s-2008-1060003.
Two male cases with Wilms' tumor in association with ambiguous genitalia and nephrotic syndrome are described. Seventeen similar cases reported in the literature are also analyzed. In these patients, nephrotic syndrome was noticed at younger ages, and progressed more rapidly than usual. Renal damage was so serious that at least 11 out of 9 patients died of renal failure, though not of Wilms' tumor itself. It should be stressed that the clinical course and associated anomalies were quite similar among these patients. We suggest that Wilms' tumor, ambiguous genitalia and this type of nephrotic syndrome may have some etiologic connection.
本文描述了两例患有肾母细胞瘤并伴有生殖器模糊和肾病综合征的男性病例。同时对文献中报道的17例类似病例进行了分析。在这些患者中，肾病综合征在较年轻时就被发现，且进展比通常情况更快。肾脏损害非常严重，尽管9例患者中至少有11例死于肾衰竭，但并非死于肾母细胞瘤本身。应当强调的是，这些患者的临床病程及相关异常情况非常相似。我们认为肾母细胞瘤、生殖器模糊和这种类型的肾病综合征可能存在某种病因学联系。
