Marshall J, Coulepis A, Pringle R, Dimitrakakis M, Gust I D
Acta Virol. 1983 Sep;27(5):429-33.
The glucocorticoid hormones dexamethasone, beta-methasone, and cortisone enhanced HBsAg release from PLC/PRF/5 cells by 40 per cent, 40 per cent and 10 per cent respectively, as compared to untreated controls. In the same experiments dexamethasone and betamethasone depressed the viable cell population by 20 per cent compared to the controls whereas cortisone had no significant effect. Immune electron microscope studies of the HBsAg material revealed no morphological differences compared to the control. Thus the glucocorticoid hormones dexamethasone, betamethasone and cortisone induce quantitative enhancement of HBsAg release without significant qualitative change. It is suggested that quantitative change in HBsAg release relates at least in part to the cell cycle of PLC/PRF/5 cells.
与未处理的对照相比，糖皮质激素地塞米松、倍他米松和可的松分别使PLC/PRF/5细胞的乙肝表面抗原（HBsAg）释放增加了40%、40%和10%。在相同实验中，与对照相比，地塞米松和倍他米松使活细胞数量减少了20%，而可的松没有显著影响。对HBsAg物质的免疫电子显微镜研究显示，与对照相比没有形态学差异。因此，糖皮质激素地塞米松、倍他米松和可的松诱导HBsAg释放的定量增加，而没有显著的定性变化。提示HBsAg释放的定量变化至少部分与PLC/PRF/5细胞的细胞周期有关。
