Ray S K, Poddar M K
Biosci Rep. 1983 Oct;3(10):973-7. doi: 10.1007/BF01140667.
Administration of a single dose (200 mg/kg, p.o.) of carbaryl to rats produced a significant rise in adrenal and plasma corticosterone levels and an increase of tyrosine alpha-ketoglutarate transaminase activity in the liver cytosol. Synaptosomal acetylcholinesterase activity of the hypothalamic and the striatal regions of rat brain was decreased by carbaryl treatment under similar conditions. Pretreatment (0.5 h) with atropine sulphate (10 mg/kg, i.p.) failed to counteract the carbaryl-induced elevation of adrenal and plasma corticosterone levels and hence the liver tyrosine alpha-ketoglutarate transaminase activity. Present results suggest that the carbaryl-induced rise in the corticosterone level in the adrenal gland and plasma is not due to a cholinergic mechanism.
给大鼠口服单剂量（200毫克/千克）西维因后，其肾上腺和血浆皮质酮水平显著升高，肝细胞溶质中的酪氨酸α-酮戊二酸转氨酶活性增加。在类似条件下，西维因处理可降低大鼠脑下丘脑和纹状体区域的突触体乙酰胆碱酯酶活性。用硫酸阿托品（10毫克/千克，腹腔注射）预处理（0.5小时）未能抵消西维因引起的肾上腺和血浆皮质酮水平升高，因此也未能抵消肝脏酪氨酸α-酮戊二酸转氨酶活性升高。目前的结果表明，西维因引起的肾上腺和血浆皮质酮水平升高并非由于胆碱能机制。
