Chan T C, Godin D V, Sutter M C
Drug Alcohol Depend. 1983 Nov;12(3):249-57. doi: 10.1016/0376-8716(83)90067-4.
There is growing evidence for essential or genetic hypertension to be associated with certain membrane abnormalities. We have published previous results on biochemical studies performed on erythrocyte membranes of the Okamoto-Aoki spontaneously hypertensive rat (SHR) and its normotensive control the WKY, reporting evidence of structural and functional alterations in the membranes. These changes could lead to increased calcium permeability and possibly compensatory increase in calcium pump activity that we observed concurrently. Chronic ethanol consumption resulted in mild hypertension in the rats used in the present study. The elevation in blood pressure is not associated with gross membrane changes in the erythrocyte. We noticed, however, that there is a slight elevation in the high affinity Ca2+/Mg2+-ATPase activities together with a trend towards higher osmotic fragility in the red cells of the ethanol-treated rats when compared with controls. These changes could be the result of concurrent reduction in plasma and membrane cholesterol contents also observed in the ethanol-treated animals.
越来越多的证据表明，原发性或遗传性高血压与某些膜异常有关。我们之前发表过对冈本-青木自发性高血压大鼠（SHR）及其血压正常的对照WKY大鼠红细胞膜进行生化研究的结果，报告了膜结构和功能改变的证据。这些变化可能导致钙通透性增加，并可能导致我们同时观察到的钙泵活性代偿性增加。在本研究使用的大鼠中，长期摄入乙醇导致轻度高血压。血压升高与红细胞膜的明显变化无关。然而，我们注意到，与对照组相比，乙醇处理大鼠的红细胞中高亲和力Ca2+/Mg2+-ATP酶活性略有升高，同时渗透脆性有升高趋势。这些变化可能是乙醇处理动物血浆和膜胆固醇含量同时降低的结果。
