Mellinger G D, Balter M B, Uhlenhuth E H
JAMA. 1984 Jan 20;251(3):375-9.
Long-term use of anxiolytics has been a cause for concern because of the possibility of dependency and other adverse consequences. In a nationally representative probability survey of adults conducted in 1979, we found that long-term use (defined as regular daily use for a year or longer) was relatively rare, occurring among 15% of all anxiolytic users--a rate of 1.6% of all adults between the ages of 18 and 79 years in the general population. The data indicate that long-term regular users tend to be older persons with high levels of emotional distress and chronic somatic health problems. They are preponderantly women, and many are sufficiently distressed to seek out other sources of help (mental health professionals and other psychotherapeutic medications) as well. The sizable majority of long-term users is being monitored by their physicians at reasonably frequent intervals. The data give little support to current stereotypes of long-term users and suggest, instead, that such use is associated with bona fide health problems that are being treated within the broader context of the health system.
长期使用抗焦虑药一直令人担忧,因为存在药物依赖及其他不良后果的可能性。在1979年进行的一项具有全国代表性的成年人概率调查中,我们发现长期使用(定义为每日规律用药一年或更长时间)相对少见,在所有抗焦虑药使用者中占15%——在18至79岁的普通人群所有成年人中占比为1.6%。数据表明,长期规律使用者往往是年龄较大、情绪困扰程度高且患有慢性躯体健康问题的人。他们以女性为主,而且许多人苦恼到足以寻求其他帮助来源(心理健康专业人员及其他精神治疗药物)。绝大多数长期使用者正由其医生以合理的频繁间隔进行监测。这些数据几乎不支持当前对长期使用者的刻板印象,反而表明这种用药与在更广泛的卫生系统背景下接受治疗的真正健康问题相关。