Potter J F, Beevers D G
Lancet. 1984 Jan 21;1(8369):119-22. doi: 10.1016/s0140-6736(84)90060-6.
The effect of alcohol on blood-pressure was studied in 16 men with hypertension who regularly drank up to 80 g of alcohol daily. Antihypertensive treatment was stopped 2 weeks before the men were admitted to hospital for a 7-day study. Blood pressure remained high in 8 patients who continued their regular alcohol consumption up to the fourth day after admission. In the next 4 days no alcohol was taken and diastolic and systolic blood pressures fell significantly. 8 other patients had no alcohol for the first 3 days after admission, but they resumed alcohol consumption from day 4 to 7. In these patients, blood pressure fell slightly after admission. Reintroduction of alcohol produced statistically significant increases in both systolic and diastolic pressures. This study demonstrated a pressor effect of alcohol in patients with hypertension and confirms the link between alcohol and blood-pressure reported in population studies. The mechanism of alcohol-induced hypertension is uncertain and is more likely to be due to an effect of alcohol rather than to the pressor response produced by alcohol withdrawal.
对16名经常每日饮酒量达80克的高血压男性进行了酒精对血压影响的研究。在这些男性入院进行为期7天的研究前2周，停止了抗高血压治疗。8名患者在入院后直至第4天继续常规饮酒，血压持续处于高位。在接下来的4天未饮酒，舒张压和收缩压显著下降。另外8名患者在入院后的前3天未饮酒，但从第4天至第7天恢复饮酒。在这些患者中，入院后血压略有下降。重新饮酒后，收缩压和舒张压在统计学上均显著升高。这项研究证明了酒精对高血压患者的升压作用，并证实了人群研究中报道的酒精与血压之间的关联。酒精性高血压的机制尚不确定，更可能是由于酒精的作用，而非酒精戒断产生的升压反应。
