Luchins D J, Meltzer H Y
Psychiatry Res. 1983 Oct;10(2):87-95. doi: 10.1016/0165-1781(83)90107-5.
In a computed tomography (CT) study, scans from 45 schizophrenic patients on an acute treatment research ward and 62 headache control subjects were blindly compared. A reliable two-dimensional measure of occipital asymmetry did not detect any differences between the two groups. Within the patient sample, however, both a correlational and group analysis indicated that absence of normal left occipital asymmetry was associated with greater psychopathology on measures of quality of interview, incomprehensibility, and auditory hallucinations. Other clinical variables including age, years of illness, previous hospitalizations, childhood adjustment, and therapeutic response to neuroleptics were not found to be related to occipital asymmetry. A relationship between absence of normal asymmetry and abnormalities of language and communication is hypothesized. Furthermore, since the original studies that noted an increased frequency of reversed asymmetry in schizophrenic patients studied populations with a very high frequency of other CT abnormalities (e.g., enlarged lateral ventricles) and this study did not, the importance of defining the relevant characteristics of schizophrenic patients with reversed occipital asymmetry is emphasized.
在一项计算机断层扫描（CT）研究中，对45名在急性治疗研究病房的精神分裂症患者和62名头痛对照受试者的扫描结果进行了盲法比较。一种可靠的枕叶不对称二维测量方法未检测到两组之间存在任何差异。然而，在患者样本中，相关性分析和组间分析均表明，在访谈质量、不可理解性和幻听测量中，枕叶正常左侧不对称的缺失与更严重的精神病理学相关。未发现其他临床变量，包括年龄、患病年限、既往住院史、儿童期适应情况以及对神经阻滞剂的治疗反应与枕叶不对称有关。推测正常不对称的缺失与语言和沟通异常之间存在关联。此外，由于最初指出精神分裂症患者中不对称反转频率增加的研究针对的是其他CT异常（如侧脑室扩大）频率非常高的人群，而本研究并非如此，因此强调了明确枕叶不对称反转的精神分裂症患者相关特征的重要性。
