Karpovich L G, Kalashnikova T V, Dzagurov S G, Blokha V V, Romanov V L, Itkin Z B, Lonskaya N I
Acta Virol. 1983 Nov;27(6):511-7.
The level and dynamics of lymphocyte blastogenesis in response to phytohaemagglutinin (PHA) and to specific influenza virus antigen were studied in 3 groups of humans, vaccinated with live or inactivated whole virion influenza vaccines (H3N2 type) and placebo (control group). Both live and inactivated influenza vaccines did not change significantly the functional activity of T lymphocytes as determined by the mean values of stimulation index (SI). The analysis of individual values of PHA-dependent blastogenic response, however, revealed a decrease in SI as compared with its prevaccination level in 33.3 +/- 11.4% of the vaccinees given the live influenza vaccine.
在3组人群中研究了对植物血凝素（PHA）和特定流感病毒抗原反应的淋巴细胞增殖水平及动力学，这3组人群分别接种了活的或灭活的全病毒体流感疫苗（H3N2型）以及安慰剂（对照组）。通过刺激指数（SI）的平均值测定发现，活疫苗和灭活流感疫苗均未显著改变T淋巴细胞的功能活性。然而，对PHA依赖的增殖反应的个体值分析显示，接种活流感疫苗的受种者中，有33.3±11.4%的人其SI与接种前水平相比有所下降。
