Ferguson A V, Veale W L, Cooper K E
Brain Res. 1984 Jan 9;290(2):297-306. doi: 10.1016/0006-8993(84)90947-8.
The experiments reported in this study were designed to investigate the influence of the early thermal environment on the functional properties of certain putative thermoregulatory neurotransmitters within the hypothalamus of the Sprague-Dawley rat. The effects on body temperature of serotonin, dopamine, carbachol, PGE2 and endotoxin when microinjected into the anterior hypothalamic/preoptic region of the brain have been examined in warm-reared, control and warm-acclimated animals. Serotonin and PGE2 are shown to have different effects on body temperature in warm-reared as compared to warm-acclimated and control animals. The thermoregulatory effects of intrahypothalamic dopamine are shown to be changed by the normal acclimation process, while carbachol and endotoxin have similar effects on the body temperature of all 3 groups of animals. These data suggest that the thermal environment may significantly affect the roles which specific neurotransmitters play in the control of body temperature.
本研究报告的实验旨在探究早期热环境对斯普拉格-道利大鼠下丘脑内某些假定的体温调节神经递质功能特性的影响。已在温暖饲养、对照和温暖适应的动物中检测了将血清素、多巴胺、卡巴胆碱、前列腺素E2和内毒素微量注射到脑的下丘脑前部/视前区时对体温的影响。结果显示，与温暖适应和对照动物相比，血清素和前列腺素E2对温暖饲养动物的体温有不同影响。下丘脑内多巴胺的体温调节作用显示会因正常的适应过程而改变，而卡巴胆碱和内毒素对所有三组动物的体温有相似影响。这些数据表明，热环境可能会显著影响特定神经递质在体温控制中所起的作用。
