Ramsey M P, Shaw G G, Newton J M, Lane E S, Sammon D C
J Pharm Pharmacol. 1984 Jan;36(1):1-6. doi: 10.1111/j.2042-7158.1984.tb02976.x.
The production of aluminium hydroxide spheres containing imipramine by gel precipitation of liquid feed solutions has been described. Washing and heating procedures applied to the precipitated spheres markedly affected the rate of drug release from the spheres into 0.1M hydrochloric acid. Increasing the imipramine content of the spheres also altered the drug release rate. The effects described have been explained with reference to model theories of the precipitation and ageing of aluminium hydroxide gels in the presence and absence of 'foreign' anions.
已描述了通过液体进料溶液的凝胶沉淀法制备含丙咪嗪的氢氧化铝球。应用于沉淀球的洗涤和加热程序显著影响了药物从球中释放到0.1M盐酸中的速率。增加球中丙咪嗪的含量也改变了药物释放速率。已参照在存在和不存在“外来”阴离子的情况下氢氧化铝凝胶沉淀和老化的模型理论对所述影响进行了解释。
